A canine mastocytoma with oncogenic c-kit activation by intra-exonic alternative splicing

A canine mastocytoma with oncogenic c-kit activation by intra-exonic alternative splicing

We report a subcutaneous mastocytoma in a mid-aged Italian greyhound dog with a small 41 bp genomic deletion of the c-kit gene leading to skipping of the authentic 3′-splice junction of intron 10. The shift to an alternative splice junction in exon 11 leads to a mis-spliced in-frame mRNA transcript...

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Bibliographic Details
Main Authors: Mengrui Li, Stephanie Vanegas, Mia R. Gonzalgo, Joseph A. Lacret, Wensi Tao, Sapna Deo, Sylvia Daunert, Jean-Marc Zingg
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Aspects of Molecular Medicine
Subjects:
Mastocytoma
Gastrointestinal stromal tumor
C-kit
Alternative splicing
Hyperthermia
Evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2949688824000066

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http://www.sciencedirect.com/science/article/pii/S2949688824000066

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