Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling that induces the nega...

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Bibliographic Details
Main Authors: Svantje Sobotta, Andreas Raue, Xiaoyun Huang, Joep Vanlier, Anja Jünger, Sebastian Bohl, Ute Albrecht, Maximilian J. Hahnel, Stephanie Wolf, Nikola S. Mueller, Lorenza A. D'Alessandro, Stephanie Mueller-Bohl, Martin E. Boehm, Philippe Lucarelli, Sandra Bonefas, Georg Damm, Daniel Seehofer, Wolf D. Lehmann, Stefan Rose-John, Frank van der Hoeven, Norbert Gretz, Fabian J. Theis, Christian Ehlting, Johannes G. Bode, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
IL-6
mathematical modeling
acute phase response
ruxolitinib
primary hepatocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00775/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00775/full

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