CARD11 regulates the thymic Treg development in an NF-κB-independent manner

CARD11 regulates the thymic Treg development in an NF-κB-independent manner

IntroductionCARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB activation downstream of the antigen receptor signal pathway. Defective CARD11 function results in abnormal development and differentiation of lymphocytes, especially thymic regulatory T cells (Treg).MethodIn thi...

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Bibliographic Details
Main Authors: Yu Hu, Lingli Han, Wenwen Xu, Tianci Li, Qifan Zhao, Wei Lu, Jinqiao Sun, Ying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
CARD11
immunodeficiency
regulatory T cells
development
FOXO1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364957/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364957/full

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