Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease

Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease

Recent studies have indicated that microRNA and VEGF are considered to be genetic modifiers and are associated with elevated levels of fetal haemoglobin HbF, and thus they reduce the clinical impact of sickle haemoglobin (HbS) patients. This cross-sectional study was performed on clinical confirmed...

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Bibliographic Details
Main Authors: Abdullah Hamadi, Rashid Mir, Ali Mahzari, Abdulrahim Hakami, Reema Almotairi, Gasim Dobie, Fawaz Hamdi, Mohammed Hassan Nahari, Razan Alhefzi, Mohammed Alasseiri, Nora Y. Hakami, Hadeel Al Sadoun, Osama M. Al-Amer, Jameel Barnawi, Hassan A. Madkhali
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Current Issues in Molecular Biology
Subjects:
sickle cell disease-SCD
microRNA-423
SNP-single-nucleotide polymorphism
ARMS-amplification refractory mutation system
OR-odds ratio
CI-confidence interval
Online Access:https://www.mdpi.com/1467-3045/44/6/175

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https://www.mdpi.com/1467-3045/44/6/175

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