BEDwARS: a robust Bayesian approach to bulk gene expression deconvolution with noisy reference signatures

BEDwARS: a robust Bayesian approach to bulk gene expression deconvolution with noisy reference signatures

Abstract Differential gene expression in bulk transcriptomics data can reflect change of transcript abundance within a cell type and/or change in the proportions of cell types. Expression deconvolution methods can help differentiate these scenarios. BEDwARS is a Bayesian deconvolution method designe...

Full description

Bibliographic Details
Main Authors: Saba Ghaffari, Kelly J. Bouchonville, Ehsan Saleh, Remington E. Schmidt, Steven M. Offer, Saurabh Sinha
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Biology
Subjects:
Bulk gene expression deconvolution
Single cell RNA-seq
Bayesian inference
Dihydropyridine dehydrogenase deficiency
Online Access:https://doi.org/10.1186/s13059-023-03007-7

Internet

https://doi.org/10.1186/s13059-023-03007-7

Similar Items