The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

Aeroplysinin-1 is a brominated isoxazoline alkaloid that has exhibited a potent antitumor cell effect in previous reports. We evaluated the cytotoxicity of aeroplysinin-1 against leukemia and prostate cancer cells in vitro. This marine alkaloid inhibited the cell proliferation of leukemia Molt-4, K5...

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Bibliographic Details
Main Authors: Shou-Ping Shih, Mei-Chin Lu, Mohamed El-Shazly, Yu-Hsuan Lin, Chun-Lin Chen, Steve Sheng-Fa Yu, Yi-Chang Liu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Life
Subjects:
apoptosis
topoisomerase
reactive oxygen species (ROS)
heat shock protein 90 (HSP90)
aeroplysinin-1 (Apl-1)
NADPH oxidases (NOXs)
Online Access:https://www.mdpi.com/2075-1729/12/5/687

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https://www.mdpi.com/2075-1729/12/5/687

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