Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations

Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations

Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause disease as each residue is under different structu...

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Bibliographic Details
Main Authors: Eric T. C. Wong, Victor So, Mike Guron, Erich R. Kuechler, Nawar Malhis, Jennifer M. Bui, Jörg Gsponer
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
intrinsically disordered proteins
single nucleotide variants
protein–protein interactions
interface core and rim
human disease
Online Access:https://www.mdpi.com/2218-273X/10/8/1097

Internet

https://www.mdpi.com/2218-273X/10/8/1097

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