Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations

Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause disease as each residue is under different structu...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Eric T. C. Wong, Victor So, Mike Guron, Erich R. Kuechler, Nawar Malhis, Jennifer M. Bui, Jörg Gsponer
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: MDPI AG 2020-07-01
Σειρά:Biomolecules
Θέματα:
Διαθέσιμο Online:https://www.mdpi.com/2218-273X/10/8/1097