A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death

A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death

ABSTRACT In both mice and humans, Type II interferon gamma (IFNγ) is crucial for the regulation of Toxoplasma gondii (T. gondii) infection, during acute or chronic phases. To thwart this defense, T. gondii secretes protein effectors hindering the host’s immune response. For example, T. gondii relies...

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Bibliographic Details
Main Authors: Brittany Henry, Aubrey J. Phillips, L. David Sibley, Alex Rosenberg
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
Subjects:
intracellular parasite
host-pathogen interactions
CRISPR screen
secretory proteins
dense granule proteins
interferon gamma
Online Access:https://journals.asm.org/doi/10.1128/mbio.02124-24

Internet

https://journals.asm.org/doi/10.1128/mbio.02124-24

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