Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

1,2-unsaturated pyrrolizidine alkaloids (PAs) are secondary plant metabolites occurring as food contaminants that can cause severe liver damage upon metabolic activation in hepatocytes. However, it is yet unknown how these contaminants enter the cells. The role of hepatic transporters is only at the...

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Bibliographic Details
Main Authors: Anne-Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Albert Braeuning, Stefanie Hessel-Pras
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
pyrrolizidine alkaloids
structure-dependency
uptake
hepatic transporter
Online Access:https://www.mdpi.com/1422-0067/22/8/3821

Internet

https://www.mdpi.com/1422-0067/22/8/3821

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