Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance <break/>Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma

Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance <break/>Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma

Mitogen-activated protein kinase (MAPK) inhibition with the combination of BRAF (Rapidly Accelerated Fibrosarcoma) and MEK (Mitogen-activated protein kinase kinase) inhibitors has become the standard of first-line therapy of metastatic melanoma harbouring BRAF V600 mutations. However, about half of...

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Bibliographic Details
Main Authors: Mohamad Krayem, Philippe Aftimos, Ahmad Najem, Tim van den Hooven, Adriënne van den Berg, Liesbeth Hovestad-Bijl, Rik de Wijn, Riet Hilhorst, Rob Ruijtenbeek, Malak Sabbah, Joseph Kerger, Ahmad Awada, Fabrice Journe, Ghanem E. Ghanem
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
mapk pathway
phosphotyrosine kinase
serine-threonine kinase
kinase inhibitors
intrinsic and acquired resistance
Online Access:https://www.mdpi.com/2072-6694/12/2/512

Internet

https://www.mdpi.com/2072-6694/12/2/512

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