Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1

Protocatechualdehyde Rescues Oxygen-Glucose Deprivation/Reoxygenation-Induced Endothelial Cells Injury by Inducing Autophagy and Inhibiting Apoptosis via Regulation of SIRT1

Background: Oxidative stress-induced endothelial cell death, such as apoptosis and autophagy, plays a critical role in ischemia-reperfusion injury. Protocatechualdehyde (PCA) is a major bioactive component of the traditional Chinese medicine Salvia miltiorrhiza Bunge (Lamiaceae), and it has been pro...

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Bibliographic Details
Main Authors: Shidong Cao, Senmiao Chen, Xilin Qiao, Yan Guo, Fang Liu, Zhishan Ding, Bo Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
protocatechualdehyde
autophagy
apoptosis
SIRT1
HUVEC
OGD/R
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.846513/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.846513/full

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