Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers. The phase solubility measurement for the supplied FFH reveal...

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Bibliographic Details
Main Authors: Basanth Babu Eedara, Dinesh Nyavanandi, Sagar Narala, Prabhakar Reddy Veerareddy, Suresh Bandari
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
fexofenadine hydrochloride
PEG 20,000
poloxamer188
dissolution
absorption
Online Access:https://www.mdpi.com/1999-4923/13/3/310

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https://www.mdpi.com/1999-4923/13/3/310

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