Direct Detection of Unnatural DNA Nucleotides dNaM and d5SICS using the MspA Nanopore.

Direct Detection of Unnatural DNA Nucleotides dNaM and d5SICS using the MspA Nanopore.

Malyshev et al. showed that the four-letter genetic code within a living organism could be expanded to include the unnatural DNA bases dNaM and d5SICS. However, verification and detection of these unnatural bases in DNA requires new sequencing techniques. Here we provide proof of concept detection o...

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Bibliographic Details
Main Authors: Jonathan M Craig, Andrew H Laszlo, Ian M Derrington, Brian C Ross, Henry Brinkerhoff, Ian C Nova, Kenji Doering, Benjamin I Tickman, Mark T Svet, Jens H Gundlach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4654578?pdf=render

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http://europepmc.org/articles/PMC4654578?pdf=render

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