Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms

Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms

Abstract Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues. In this study, we report the cryo-EM structure of pannexin 3 at 3.9 Å and analyze it...

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Bibliographic Details
Main Authors: Nazia Hussain, Ashish Apotikar, Shabareesh Pidathala, Sourajit Mukherjee, Ananth Prasad Burada, Sujit Kumar Sikdar, Kutti R. Vinothkumar, Aravind Penmatsa
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47142-6

Internet

https://doi.org/10.1038/s41467-024-47142-6

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