Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone

Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone

Aims: Transcription factor nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases in all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate chronic inflammation has had limited success in preclinical studies. We hypothesize...

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Bibliographic Details
Main Authors: Masakazu Toya, Junichi Kushioka, Huaishuang Shen, Takeshi Utsunomiya, Hirohito Hirata, Masanori Tsubosaka, Qi Gao, Simon K. Chow, Ning Zhang, Stuart B. Goodman
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2024-01-01
Series:Bone & Joint Research
Subjects:
sex differences
osteogenesis
nf-κb
inflammation
targeted therapy
osteoporosis
polyethylene
rt-pcr
tartrate-resistant acid phosphatase staining
nuclear factor kappa b
gene expressions
bone resorption
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.131.BJR-2023-0040.R3

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.131.BJR-2023-0040.R3

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