Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive.In the...

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Bibliographic Details
Main Authors: Janice B B Lam, Kim H M Chow, Aimin Xu, Karen S L Lam, Jing Liu, Nai-Sum Wong, Randall T Moon, Peter R Shepherd, Garth J S Cooper, Yu Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2656613?pdf=render

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http://europepmc.org/articles/PMC2656613?pdf=render

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