Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy

Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for a number of hemato-oncological disorders. In fact, allo-HSCT is considered as one of the most successful immunotherapies as its clinical efficacy is based on the donor T-cells’ capacity t...

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Bibliographic Details
Main Authors: Regina Jitschin, Simon Völkl, Andreas Mackensen, Dimitrios Mougiakakos, Andreas Gießl, Heiko Bruns, Martin Böttcher, Rebecca Baur, Andrej Stoll, Thomas Fischer, Franziska Karl, Romy Böttcher-Loschinski, Cindy Flamann, Ursula Schlötzer-Schrehardt, Denis M Schewe
Format: Article
Language:English
Published: BMJ Publishing Group 2023-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/3/e006362.full

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https://jitc.bmj.com/content/11/3/e006362.full

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