Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis
Cystic fibrosis (CF) is caused by genetic mutations that affect the cystic fibrosis transmembrane conductance regulator (CFTR) protein. These mutations can impact the synthesis and transfer of the CFTR protein to the apical membrane of epithelial cells, as well as influencing the gating or conductan...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2013-03-01
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| Series: | European Respiratory Review |
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| Online Access: | http://err.ersjournals.com/content/22/127/58.full.pdf+html |