ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis

Abstract A disintegrin and metalloprotease-10(ADAM10) promotes the metastasis of prostate cancer (PCa), but the specific mechanism is indistinct. Herein, DU145 cell lines with stable overexpression and knockdown of ADAM10 were constructed. We found that ectopic expression of ADAM10 not only signific...

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Bibliographic Details
Main Authors: Chenchen Cai, Miaomiao Zhang, Lei Liu, Haoliang Zhang, Yi Guo, Ting Lan, Yinhai Xu, Ping Ma, Shibao Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04893-8