BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial

BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial

Abstract Acellular pertussis (aP) booster vaccines are central to pertussis immunization programs, although their effectiveness varies. The Bacille Calmette-Guérin (BCG) vaccine is a prototype inducer of trained immunity, which enhances immune responses to subsequent infections or vaccinations. Whil...

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Bibliographic Details
Main Authors: Joshua Gillard, Bastiaan A. Blok, Daniel R. Garza, Prashanna Balaji Venkatasubramanian, Elles Simonetti, Marc J. Eleveld, Guy A. M. Berbers, Pieter G. M. van Gageldonk, Irma Joosten, Ronald de Groot, L. Charlotte J. de Bree, Reinout van Crevel, Marien I. de Jonge, Martijn A. Huynen, Mihai G. Netea, Dimitri A. Diavatopoulos
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00438-4

Internet

https://doi.org/10.1038/s41541-022-00438-4

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