Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limi...

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Bibliographic Details
Main Authors: John P. Murad, Anna K. Kozlowska, Hee Jun Lee, Maya Ramamurthy, Wen-Chung Chang, Paul Yazaki, David Colcher, John Shively, Mihaela Cristea, Stephen J. Forman, Saul J. Priceman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
ovarian cancer
regional intraperitoneal delivery
TAG72
tumor-associated glycoproteins
adoptive cellular immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02268/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02268/full

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