The two-domain architecture of LAMP2A within the lysosomal lumen regulates its interaction with HSPA8/Hsc70

The two-domain architecture of LAMP2A within the lysosomal lumen regulates its interaction with HSPA8/Hsc70

Chaperone-mediated autophagy (CMA) is a unique proteolytic pathway, in which cytoplasmic proteins recognized by HSPA8/Hsc70 (heat shock protein 8) are transported into lysosomes for degradation. LAMP2A (lysosomal-associated membrane protein 2A) recruits the substrate/chaperone complex to the lysosom...

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Bibliographic Details
Main Authors: Yuta Ikami, Kazue Terasawa, Tetsuro Watabe, Shigeyuki Yokoyama, Miki Hara-Yokoyama
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Autophagy Reports
Subjects:
chaperone-mediated autophagy
expanded genetic codes
hspa8
lamp2a
site-specific photo-crosslinking
site-specific steric hindrance
Online Access:http://dx.doi.org/10.1080/27694127.2022.2069968

Internet

http://dx.doi.org/10.1080/27694127.2022.2069968

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