Single-cell Sequencing Reveals Clearance of Blastula Chromosomal Mosaicism in In Vitro Fertilization Babies

Single-cell Sequencing Reveals Clearance of Blastula Chromosomal Mosaicism in In Vitro Fertilization Babies

Although chromosomal mosaic embryos detected by trophectoderm (TE) biopsy offer healthy embryos available for transfer, high-resolution postnatal karyotyping and chromosome testing of the transferred embryos are insufficient. Here, we applied single-cell multi-omics sequencing for seven infants with...

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Bibliographic Details
Main Authors: Yuan Gao, Jinning Zhang, Zhenyu Liu, Shuyue Qi, Xinmeng Guo, Hui Wang, Yanfei Cheng, Shuang Tian, Minyue Ma, Hongmei Peng, Lu Wen, Fuchou Tang, Yuanqing Yao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Mosaicism
Pre-implantation genetic testing for aneuploidy
Next-generation sequencing
Single-cell multi-omics sequencing
Mosaic embryo transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022922000882

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http://www.sciencedirect.com/science/article/pii/S1672022922000882

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