The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression and other disorders often show anergia, psychomotor retardation, fatigue, a...

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Bibliographic Details
Main Authors: Patrick A Randall, Christie A Lee, Eric J Nunes, Samantha E Yohn, Victoria Nowak, Bilal Khan, Priya Shah, Saagar Pandit, V Kiran Vemuri, Alex Makriyannis, Younis Baqi, Christa E Müller, Merce Correa, John D Salamone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4061002?pdf=render

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http://europepmc.org/articles/PMC4061002?pdf=render

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