Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis

Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis

Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders. Dimeric molecules have been reported to have an especially potent modulating effect, due to the U-shaped form of the AM...

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Bibliographic Details
Main Authors: Kseniya N. Sedenkova, Denis V. Zverev, Anna A. Nazarova, Mstislav I. Lavrov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel’yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
pyrimidines
S<sub>N</sub>Ar reactions
bis(pyrimidine)
bivalent ligand
ionotropic glutamate receptors
AMPA receptor
Online Access:https://www.mdpi.com/1420-3049/27/23/8252

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https://www.mdpi.com/1420-3049/27/23/8252

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