Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer's disease in vivo.

Mouse Alzheimer's disease (AD) models develop age- and region-specific pathology throughout the hippocampal formation. One recently established pathological correlate is an increase in hippocampal excitability in vivo. Hippocampal pathology also produces episodic memory decline in human AD and...

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Bibliographic Details
Main Authors: Katherine E Davis, Sarah Fox, John Gigg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3951322?pdf=render