A Beckwith–Wiedemann-Associated <i>CDKN1C</i> Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57<sup>Kip2</sup>

A Beckwith–Wiedemann-Associated <i>CDKN1C</i> Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57<sup>Kip2</sup>

p57<sup>Kip2</sup> protein is a member of the CIP/Kip family, mainly localized in the nucleus where it exerts its Cyclin/CDKs inhibitory function. In addition, the protein plays key roles in embryogenesis, differentiation, and carcinogenesis depending on its cellular localization and int...

Full description

Bibliographic Details
Main Authors: Emanuela Stampone, Debora Bencivenga, Clementina Barone, Marilena Di Finizio, Fulvio Della Ragione, Adriana Borriello
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Beckwith–Wiedemann syndrome
<i>CDKN1C</i> mutations
NLS
p57<sup>Kip2</sup>
R316W-p57<sup>Kip2</sup>
Online Access:https://www.mdpi.com/1422-0067/22/14/7428

Internet

https://www.mdpi.com/1422-0067/22/14/7428

Similar Items