Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination

Abstract Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated wit...

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Bibliographic Details
Main Authors: Jeremy Setton, Pier Selenica, Semanti Mukherjee, Rachna Shah, Isabella Pecorari, Biko McMillan, Isaac X. Pei, Yelena Kemel, Ozge Ceyhan-Birsoy, Margaret Sheehan, Kaitlyn Tkachuk, David N. Brown, Liying Zhang, Karen Cadoo, Simon Powell, Britta Weigelt, Mark Robson, Nadeem Riaz, Kenneth Offit, Jorge S. Reis-Filho, Diana Mandelker
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00339-0

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https://doi.org/10.1038/s41523-021-00339-0

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