Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice

Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice

Alveolar epithelial cells (AECs) injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis (PF). Nevertheless, the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear. SMARCA4 is a part of the large...

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Bibliographic Details
Main Authors: Danyi Peng, Daozhu Si, Rong Zhang, Jiang Liu, Hao Gou, Yunqiu Xia, Daiyin Tian, Jihong Dai, Ke Yang, Enmei Liu, Yujun Shi, Q. Richard Lu, Lin Zou, Zhou Fu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-12-01
Series:Genes and Diseases
Subjects:
Cell proliferation
Pulmonary fibrosis
SMARCA4
Transgenic mice
Type II alveolar epithelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304217300636

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http://www.sciencedirect.com/science/article/pii/S2352304217300636

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