Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis

Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis

Abstract Background There is increasing evidence that mesenchymal stem cells (MSCs) help shape the tumor microenvironment and promote tumor progression, and ion channels might play a critical role in this process. The objective of the present study was to explore the function and mechanism of MT-CAF...

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Bibliographic Details
Main Authors: Chunling Xue, Yang Gao, Xuechun Li, Mingjia Zhang, Ying Yang, Qin Han, Zhao Sun, Chunmei Bai, Robert Chunhua Zhao
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Colon cancer
Growth and metastasis
TRPC3
NF-KB signaling pathway
Prognosis
Online Access:https://doi.org/10.1186/s13287-022-03017-5

Internet

https://doi.org/10.1186/s13287-022-03017-5

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