Hemin-Induced Endothelial Dysfunction and Endothelial to Mesenchymal Transition in the Pathogenesis of Pulmonary Hypertension Due to Chronic Hemolysis

Hemin-Induced Endothelial Dysfunction and Endothelial to Mesenchymal Transition in the Pathogenesis of Pulmonary Hypertension Due to Chronic Hemolysis

Pulmonary hypertension in sickle cell disease is an independent predictor of mortality, yet the pathogenesis of pulmonary vascular disease in chronic hemolytic disorders remains incompletely understood and treatment options are limited primarily to supportive care. The release of extracellular hemog...

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Bibliographic Details
Main Authors: Janae Gonzales, Kelsey Holbert, Kamryn Czysz, Joseph George, Caroline Fernandes, Dustin R. Fraidenburg
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial dysfunction
endothelial to mesenchymal transition
pulmonary hypertension
hemolysis
Online Access:https://www.mdpi.com/1422-0067/23/9/4763

Internet

https://www.mdpi.com/1422-0067/23/9/4763

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