CRISPR/Cas9 Directed Reprogramming of iPSC for Accelerated Motor Neuron Differentiation Leads to Dysregulation of Neuronal Fate Patterning and Function

CRISPR/Cas9 Directed Reprogramming of iPSC for Accelerated Motor Neuron Differentiation Leads to Dysregulation of Neuronal Fate Patterning and Function

Neurodegeneration causes a significant disease burden and there are few therapeutic interventions available for reversing or slowing the disease progression. Induced pluripotent stem cells (iPSCs) hold significant potential since they are sourced from adult tissue and have the capacity to be differe...

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Bibliographic Details
Main Authors: Katie Davis-Anderson, Sofiya Micheva-Viteva, Emilia Solomon, Blake Hovde, Elisa Cirigliano, Jennifer Harris, Scott Twary, Rashi Iyer
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR/Cas9 gene editing
iPSC reprogramming
motor neuron development
global transcriptome
electrophysiological activity
Online Access:https://www.mdpi.com/1422-0067/24/22/16161

Internet

https://www.mdpi.com/1422-0067/24/22/16161

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