Stability of Naked Nucleic Acids under Physical Treatment and Powder Formation: Suitability for Development as Dry Powder Formulations for Inhalation

Stability of Naked Nucleic Acids under Physical Treatment and Powder Formation: Suitability for Development as Dry Powder Formulations for Inhalation

A number of functional nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), have been attracting increasing attention as new therapeutic modalities worldwide. Dry pDNA and siRNA powder formulations for inhalation are considered practical in clinical applications for respira...

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Bibliographic Details
Main Authors: Tomoyuki Okuda, Maki Okazaki, Akihiko Hayano, Hirokazu Okamoto
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceutics
Subjects:
nucleic-acid-based medicines
physical stress
powder formation
stability
dry powder inhaler (DPI) formulations
plasmid DNA (pDNA)
Online Access:https://www.mdpi.com/1999-4923/15/12/2786

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https://www.mdpi.com/1999-4923/15/12/2786

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