Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium

Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium

Hemolytic uremic syndrome (HUS) is a severe renal disease that is often preceded by infection with Shiga toxin (Stx)-producing <i>Escherichia coli</i> (STEC). The exact mechanism of Stx-mediated inflammation on human glomerular microvascular endothelial cells (HGMVECs) during HUS is stil...

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Bibliographic Details
Main Authors: Elena B. Volokhina, Wouter J. C. Feitz, Lonneke M. Elders, Thea J. A. M. van der Velden, Nicole C. A. J. van de Kar, Lambertus P. W. J. van den Heuvel
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Toxins
Subjects:
hemolytic uremic syndrome
human glomerular microvascular endothelium
Shiga toxin 1
gene expression
heparan sulfate proteoglycans
syndecan-4
Online Access:https://www.mdpi.com/2072-6651/12/7/435

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https://www.mdpi.com/2072-6651/12/7/435

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