Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer

Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer

Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein is known to play a critical role as a potential driver oncogen...

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Bibliographic Details
Main Authors: Sandrina Körner, Tillman Pick, Florian Bochen, Silke Wemmert, Christina Körbel, Michael D. Menger, Adolfo Cavalié, Jan-Philipp Kühn, Bernhard Schick, Maximilian Linxweiler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
Sec62
head and neck cancer
CRISPR/ Cas9
lymphogenic metastasis
xenograft model
trifluoperazine
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.880004/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.880004/full

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