Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising agonists with no or low (...

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Bibliographic Details
Main Authors: Barbora Vyhlídalová, Kristýna Krasulová, Petra Pečinková, Adéla Marcalíková, Radim Vrzal, Lenka Zemánková, Jan Vančo, Zdeněk Trávníček, Jan Vondráček, Martina Karasová, Sridhar Mani, Zdeněk Dvořák
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
aryl hydrocarbon receptor
tryptophan
indoles
microbiome
Online Access:https://www.mdpi.com/1422-0067/21/7/2614

Internet

https://www.mdpi.com/1422-0067/21/7/2614

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