Differential CMS-Related Expression of Cell Surface Carbonic Anhydrases IX and XII in Colorectal Cancer Models—Implications for Therapy

Differential CMS-Related Expression of Cell Surface Carbonic Anhydrases IX and XII in Colorectal Cancer Models—Implications for Therapy

Tumor-associated carbonic anhydrases IX (CAIX) and XII (CAXII) have long been in the spotlight as potential new targets for anti-cancer therapy. Recently, CAIX/CAXII specific inhibitor SLC-0111 has passed clinical phase I study and showed differential response among patients with colorectal cancer (...

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Bibliographic Details
Main Authors: Arne Rotermund, Sarah Brandt, Martin S. Staege, Jana Luetzkendorf, Lutz P. Mueller, Thomas Mueller
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
carbonic anhydrases
colorectal cancer
consensus molecular subtypes
CMS
SLC-0111
targeted inhibition of carbonic anhydrases
Online Access:https://www.mdpi.com/1422-0067/24/6/5797

Internet

https://www.mdpi.com/1422-0067/24/6/5797

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