alpha-Globin genes: thalassemic and structural alterations in a Brazilian population

Seven unrelated patients with hemoglobin (Hb) H disease and 27 individuals with alpha-chain structural alterations were studied to identify the alpha-globin gene mutations present in the population of Southeast Brazil. The -alpha3.7, --MED and -(alpha)20.5 deletions were investigated by PCR, whereas...

Full description

Bibliographic Details
Main Authors: M.R.S.C. Wenning, E.M. Kimura, F.F. Costa, S.T.O. Saad, S. Gervásio, S.B. de Jorge, E. Borges, N.M. Silva, M.F. Sonati
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2000-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900008