Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy

Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy

PDCD4 (programmed cell death 4) is a tumor suppressor that plays a crucial role in multiple cellular functions, such as the control of protein synthesis and transcriptional control of some genes, the inhibition of cancer invasion and metastasis. The expression of this protein is controlled by synthe...

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Bibliographic Details
Main Authors: M. Manirujjaman, Iwata Ozaki, Yuzo Murata, Jing Guo, Jinghe Xia, Kenichi Nishioka, Rasheda Perveen, Hirokazu Takahashi, Keizo Anzai, Sachiko Matsuhashi
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
autophagy
p62/sqstm1
pdcd4
proteasome
ubiquitination
Online Access:https://www.mdpi.com/2073-4409/9/1/218

Internet

https://www.mdpi.com/2073-4409/9/1/218

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