Synthesis, DNA Binding and Topoisomerase I Inhibition Activity of Thiazacridine and Imidazacridine Derivatives

Synthesis, DNA Binding and Topoisomerase I Inhibition Activity of Thiazacridine and Imidazacridine Derivatives

Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the mechanism of action of these compounds, binding studies of 5-acridin-9-ylmethylidene-3-amino-2-thioxo-thiazolidin-4-one, 5-acridin-9-ylmethylid...

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Bibliographic Details
Main Authors: Elizabeth Almeida Lafayette, Sinara Mônica Vitalino de Almeida, Marina Galdino da Rocha Pitta, Eduardo Isidoro Carneiro Beltrão, Teresinha Gonçalves da Silva, Ricardo Olímpio de Moura, Ivan da Rocha Pitta, Luiz Bezerra de Carvalho, Maria do Carmo Alves de Lima
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
thiazacridine
imidazacridine
DNA binding
topoisomerase I inhibitor
Online Access:http://www.mdpi.com/1420-3049/18/12/15035

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http://www.mdpi.com/1420-3049/18/12/15035

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