Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy

Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor metabolite 2-hydroxyglutaric acid (2-HG), cau...

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Bibliographic Details
Main Authors: LIN Meijia, ZENG Yeting, WANG Xinrui, HUANG Xiongfei
Format: Article
Language:zho
Published: Editorial Office of Medical Journal of Peking Union Medical College Hospital 2023-03-01
Series:Xiehe Yixue Zazhi
Subjects:
isocitrate dehydrogenase mutation
2-hydroxyglutaric acid
chemotherapy
immunotherapy
targeted therapy
Online Access:https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0176

Internet

https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0176

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