Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex multi-factorial neurodegenerative disorder for which only few drugs (including donepezil, DPZ) are available as symptomatic treatments; thus, researchers are focusing on the development of innovative multi-target directed ligands (MTDLs), which could also alter...

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Bibliographic Details
Main Authors: Alessia Carocci, Alexia Barbarossa, Rosalba Leuci, Antonio Carrieri, Leonardo Brunetti, Antonio Laghezza, Marco Catto, Francesco Limongelli, Sílvia Chaves, Paolo Tortorella, Cosimo Damiano Altomare, Maria Amélia Santos, Fulvio Loiodice, Luca Piemontese
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
neurodegeneration
antioxidants
multi-functional drugs
donepezil
phenothiazine
Online Access:https://www.mdpi.com/2076-3921/11/9/1631

Internet

https://www.mdpi.com/2076-3921/11/9/1631

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