Single‐Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T‐Cell Lymphoma

Single‐Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T‐Cell Lymphoma

Abstract Extranodal natural killer/T‐cell lymphoma (NKTCL) is an aggressive type of lymphoma associated with Epstein–Barr virus (EBV) and characterized by heterogeneous tumor behaviors. To better understand the origins of the heterogeneity, this study utilizes single‐cell RNA sequencing (scRNA‐seq)...

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Bibliographic Details
Main Authors: Yi‐Qi Li, Chun‐Ling Luo, Jia‐Xin Jiang, Shuai He, Yang Liu, Wen‐Xin Yan, Yi Xia, Qian Cui, Ying Huang, Jing Quan Lim, Dachuan Huang, Izzah Nabilah Hussein, Yan Gao, Guo‐Wang Lin, Yi‐Hong Ling, Dong Ma, Yue‐Tong Zhang, Jason Yongsheng Chan, Pan‐Pan Wei, Xiao‐Xiao Wang, Chee Leong Cheng, Jie Xiong, Wei‐Li Zhao, Choon Kiat Ong, Soon Thye Lim, Hui‐Qiang Huang, Rou‐Jun Peng, Jin‐Xin Bei
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
DPP4
immunosuppression
LMP1+ malignant NK cells
NKTCL
scRNA‐seq
Online Access:https://doi.org/10.1002/advs.202303913

Internet

https://doi.org/10.1002/advs.202303913

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