Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G.

Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G.

Although intravenous immunoglobulin (IVIG) is highly effective in Kawasaki disease (KD), mechanisms are not understood and 10-20% of patients are treatment-resistant, manifesting a higher rate of coronary artery aneurysms. Murine models suggest that α2-6-linked sialic acid (α2-6Sia) content of IVIG...

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Bibliographic Details
Main Authors: Shohei Ogata, Chisato Shimizu, Alessandra Franco, Ranim Touma, John T Kanegaye, Biswa P Choudhury, Natasha N Naidu, Yutaka Kanda, Long T Hoang, Martin L Hibberd, Adriana H Tremoulet, Ajit Varki, Jane C Burns
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855660?pdf=render

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http://europepmc.org/articles/PMC3855660?pdf=render

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