The Pharmacokinetics of Medetomidine Administered Subcutaneously during Isoflurane Anaesthesia in Sprague-Dawley Rats

The Pharmacokinetics of Medetomidine Administered Subcutaneously during Isoflurane Anaesthesia in Sprague-Dawley Rats

Anaesthetic protocols involving the combined use of a sedative agent, medetomidine, and an anaesthetic agent, isoflurane, are increasingly being used in functional magnetic resonance imaging (fMRI) studies of the rodent brain. Despite the popularity of this combination, a standardised protocol for t...

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Bibliographic Details
Main Authors: Leila T. Kint, Bhedita J. Seewoo, Timothy H. Hyndman, Michael W. Clarke, Scott H. Edwards, Jennifer Rodger, Kirk W. Feindel, Gabrielle C. Musk
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Animals
Subjects:
functional MRI
rat anaesthesia
refinement
Online Access:https://www.mdpi.com/2076-2615/10/6/1050

Internet

https://www.mdpi.com/2076-2615/10/6/1050

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