Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility

Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility

Classical and accelerated molecular dynamics simulations reveal how core fucosylation in the IgG1 Fc glycan and the light chain isotype modulate the conformational behavior of the hinge and Fab domains and dynamics of IgG1 antibodies.

Bibliographic Details
Main Authors: Simona Saporiti, Tommaso Laurenzi, Uliano Guerrini, Crescenzo Coppa, Wolf Palinsky, Giulia Benigno, Luca Palazzolo, Omar Ben Mariem, Linda Montavoci, Mara Rossi, Fabio Centola, Ivano Eberini
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04622-7

Internet

https://doi.org/10.1038/s42003-023-04622-7

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