Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells

Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells

Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all-<i>trans</i> reti...

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Bibliographic Details
Main Authors: Jacopo Albanesi, Nelida Ines Noguera, Cristina Banella, Tommaso Colangelo, Elisabetta De Marinis, Stefano Leone, Orazio Palumbo, Maria Teresa Voso, Paolo Ascenzi, Clara Nervi, Fabrizio Bianchi, Alessandra di Masi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
acute promyelocytic leukemia
aerobic glycolysis
all-trans-retinoic acid
DNA repair
epigenetic regulators
immune cell response
Online Access:https://www.mdpi.com/2073-4409/9/11/2423

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https://www.mdpi.com/2073-4409/9/11/2423

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