In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2

In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2

The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous in vitro study showed that Pelargonium sidoides DC. root extract EPs® 7630 has combined antiviral and immunomodulatory properties in SARS-CoV-2-infected human lu...

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Bibliographic Details
Main Authors: Jackson Emanuel, Jan Papies, Celine Galander, Julia M. Adler, Nicolas Heinemann, Kathrin Eschke, Sophie Merz, Hannah Pischon, Ruben Rose, Andi Krumbholz, Žarko Kulić, Martin D. Lehner, Jakob Trimpert, Marcel A. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
coronavirus
Pelargonium sidoides
EPs 7630
drug repurposing
immune modulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1214351/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1214351/full

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