Study protocol for safety and efficacy of all-oral shortened regimens for multidrug-resistant tuberculosis: a multicenter randomized withdrawal trial and a single-arm trial [SEAL-MDR]

Study protocol for safety and efficacy of all-oral shortened regimens for multidrug-resistant tuberculosis: a multicenter randomized withdrawal trial and a single-arm trial [SEAL-MDR]

Abstract Introduction The urgent need for new treatments for multidrug-resistant tuberculosis (MDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is evident. However, the classic randomized controlled trial (RCT) approach faces ethical and practical constraints, making alternative...

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Bibliographic Details
Main Authors: Liang Fu, Juan Xiong, Haibo Wang, Peize Zhang, Qianting Yang, Yi Cai, Wenfei Wang, Feng Sun, Xilin Zhang, Zhaoqin Wang, Xinchun Chen, Wenhong Zhang, Guofang Deng
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Infectious Diseases
Subjects:
Multidrug-resistant
Tuberculosis
Efficacy
Safety
Trial
Online Access:https://doi.org/10.1186/s12879-023-08644-8

Internet

https://doi.org/10.1186/s12879-023-08644-8

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